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Future research must therefore pivot toward integrated, multi-targeted nutritional strategies that simultaneously address these interconnected pathways, moving beyond single-nutrient approaches to achieve personalized OA management (35)

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Strikingly, simply increasing mitochondrial GSH levels by expressing mito-GSHf in SLC25A39/40 double knockout cells completely restored the reduced levels of mitochondrial translation machinery proteins, iron-sulfur containing proteins, and aconitase activity (Fig 4f,g)

This powerful effect was particularly important during the peak outbreak of COVID-19 where it was suggested as a possible supplement to help suppress the widespread inflammation often leading to organ failure

Cell 155 , 14221434 (2013)