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However, when HepaRG stem-cell derived human hepatocytes were subjected to APAP, the same mechanisms of hepatotoxicity were demonstratedstarting with GSH depletion and moving through protein adduct formation, superoxide and peroxynitrite formation and lysosomal iron uptake into mitochondria

Duncan MR, Berman B, Nseyo UO

In Section 3.2, we show that the steady-state concentration of GSH varies as S varies over a wide range, 1-3.5, but is fairly homeostatic near 1.8

Retrieved September 5, 2016

Naturally present in every cell, it is a peptide molecule composed of three amino acids: glutamine, cysteine, and glycine