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At the time I was too sick to really notice a difference but I got a crash course on peptides
10.1016/j.pmpp.2005.03.007 179 ZeierJ.PinkB.MuellerM
The slight acidity of the solution (pH approximately 3.04.0 at 0.1% concentration) protonates basic amino acid residues on poorly water-soluble peptides, increasing their net positive charge and improving electrostatic interaction with the surrounding aqueous solvent a mechanism that dramatically increases the solubility of many lyophilised peptide preparations that resist dissolution in neutral or alkaline aqueous conditions
Off-label clinical use is expanding into specialized centers, with Palatin Technologies also launching a Phase 2 study of bremelanotide co-administered with a PDE5 inhibitor for ED patients who dont respond to PDE5i monotherapy with Phase 3 advancement planned for 2025
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