Contraindications Given the limited safety data, conservative contraindications would include pregnancy or plans to become pregnant, breastfeeding, age under 18, severe liver or kidney disease, and any condition requiring medications with unknown interaction potential
But stress, medications, aging, and bad health can deplete glutathione levels
Inclusion criteria encompassed all studies employing in vitro models (e.g., fibroblast proliferation, keratinocyte migration, collagen synthesis assays), in vivo studies using animal models for wound healing assessments, clinical trials evaluating the efficacy and safety of tripeptides in human subjects, and studies utilizing molecular, biochemical, or histological analyses to determine the mechanisms of tripeptides in wound recovery
Statistical analysis All statistical analysis was completed using either R or GraphPad Prism (v.10.6.1)
Additionally, we demonstrated that the prethrombotic state induced by moderate hyperhomocysteinemia occurs during oxidant stress in rats (Durand et al, 1996b