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The weight effect runs through several parallel mechanisms: it activates satiety centers in the hypothalamus so patients feel full sooner and stay full longer, it slows gastric emptying, it modulates reward pathways so calorie-dense foods feel less compelling, and it stabilizes post-meal glucose and insulin

I reviewed the latest research and spoke with four experts to get a clearer picture of what GLP-1 supplements really are and whether they're worth your time (or money)

2 With rising off-label use of GLP-1s in PCOS, comparative evidence with metformin is needed to inform clinical practice and health policy