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Packer M, Zile MR, Kramer CM, Baum SJ, Litwin SE, Menon V, Ge J, Weerakkody GJ, Ou Y, Bunck MC, Hurt KC, Murakami M, Borlaug BA, SUMMIT Trial Study Group

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Nicotine, like alcohol, activates the brains reward systems, leading to the release of dopamine, which reinforces the habit of smoking

The phase 3 TRIUMPH-4 trial confirmed and extended these findings

Chemical depletion of glutathione in vivo