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The cardiovascular community, expecting the usual incremental class effect, instead got the SELECT trial, a 20% reduction in major adverse cardiovascular events in patients with overweight or obesity and established cardiovascular disease, in patients without diabetes

However, its potential in aiding weight loss was soon recognized, leading to its approval for this purpose under the brand name Wegovy

Safety considerations Available evidence suggests that combined therapy with SGLT2 inhibitors and GLP-1 receptor agonists is generally well tolerated, with safety profiles largely consistent with those of each class individually [24, 40,41,42,43]

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[1] [2] [3] [4] In support of energy metabolism, carnitine transports long-chain fatty acids from the cytosol into mitochondria to be oxidized for free energy production, and also participates in removing products of metabolism from cells