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In man the liver and the kidney synthesize the remaining 25 % from the immediate precursor gamma butyrobetaine 3, 4

The glutathione system comprises the enzymes that synthesize glutathione within a cell as well as dedicated enzymes that use glutathione (GSH) as the means to exert antioxidant effects

Nigam, S., Ciccoli, R., Ivanov, I., Sczepanski, M