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Combination of GPX4 Activator With 5-LOX Inhibitor Furthermore, we applied compound 102 with Zileuton, a 5-LOX inhibitor clinically used as an anti-asthmatic drug with reported hepatotoxicity and neuropsychiatric side effects according to the FDA

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Animals were anesthetized intramuscularly with a ketaminexylazine mixture composed of 30 mg/kg ketamine and 12 mg/kg xylazine, respectively, with a total injection volume of 1.2 mL/kg