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Dynamically, Drp1-mediated mitochondrial fission is preferentially activated, leading to mitochondrial network fragmentation, while the expression of fusion proteins (e.g., Mfn1/2, OPA1) remains relatively unchanged in the initial phase, reflecting a fission-dominant imbalance

It is essential for regulating the growth and function of immune cells, and Zn homeostasis can regulate cell signal transduction [74, 75]

Tendons and ligaments often fall into this group

[90] A second enzyme, methylenetetrahydrofolate dehydrogenase (MTHFD2) [93] oxidizes 5,10-methylenetetrahydrofolate to an iminium cation which in turn is hydrolyzed to produce 5-formyl-THF and 10-formyl-THF

Pollak 2008) has linked higher circulating IGF-1 to elevated risk of certain cancers in human cohorts