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GLP-1s changed my life. Vanessa Williams, 63 In a January 2026 cover story for Hello

Measurable weight loss usually appears between weeks eight and twelve

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But the real-world data tells a different, far more interesting story

The first case involves a 54-year-old man who, about one month after starting semaglutide, experienced a marked decline in energy, motivation, fatigue, difficulty concentrating, and mood disturbances