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Effect of thiols on the reductive activation rate

In order to determine the impact of elevated GSH on artemisinin potency, we pre-treated artemisinin resistant (Cam3.II C580Y ) and sensitive (Cam3.II REV ) parasites with N-acetyl cysteine (NAC), a precursor for GSH de novo synthesis 46 and measured sensitivity to 700 nM of DHA by RSA

Duration: Typically continued for several weeks to months, depending on patient response

In Alzheimers disease models, spine loss in the hippocampus is one of the earliest and most consistent pathological findings

It is made up of three amino acids: cysteine, glutamic acid, and glycine