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It's important to note that these are not established adverse drug reactions in the UK product information (SmPC) for tirzepatide, and no causal relationship has been confirmed: Low mood or depressive symptoms some individuals have reported feelings of sadness or emotional flatness Anxiety or irritability heightened nervousness or shorter temper in certain cases Fatigue and reduced motivation sporadically reported but not established as medication effects Changes in appetite and food relationships the medication's appetite-suppressing effects may alter social eating patterns and emotional connections to food These effects do not affect the majority of patients taking Mounjaro

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This mechanism has legitimate scientific support