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The safety and tolerability profile of retatrutide observed in the phase 2 trial was broadly consistent with that of other incretin-based therapies, including GLP-1 receptor agonists

Following any MHRA marketing authorisation, NICE (the National Institute for Health and Care Excellence) would be expected to conduct a technology appraisal to determine whether retatrutide represents a cost-effective use of NHS resources and to establish guidance on appropriate patient populations

So in patients for whom this matters, who may have heart disease, kidney disease, or obesity complications, then the benefits of GLP-1s do outweigh the potential risks, which are typically gastrointestinal side effects

Semaglutide-eye-catching results

Approximately 100200 Ci of 89 Zr-labelled AuNPs or 18 F-labelled Phe-BF 3 was then tail-vein injected into mice to observe their metabolic distribution in vivo