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\n\n\n\n The compounds multimechanistic nature also makes it challenging to evaluate through conventional clinical trial frameworks, which are typically designed around single-mechanism drugs with well-defined target receptors and predictable dose-response relationships
Acknowledgements This work was supported by Ministero dellIstruzione, dellUniversit e della Ricerca of Italy, Progetto PONRicerca e Competitivit 20072013PON01_01802: Sviluppo di molecole capaci di modulare vie metaboliche intracellulari redoxsensibili per la prevenzione e la cura di patologie infettive, tumorali, neurodegenerative e loro delivery mediante piattaforme nano tecnologiche, and PON01_02512: Ricerca e sviluppo di bioregolatori attivi sui meccanismi epigenetici dei processi infiammatori nelle malattie croniche e degenerative
The potential for receptor desensitization over extended periods is a theoretical concern with any agent that continuously stimulates a receptor
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The combination tends to shine during stress, fatigue, or high cognitive demand
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