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The increase in gastrointestinal problems has been well-documented, and the rise in low blood pressure and kidney stones is probably because GLP-1 patients could be somewhat fluid-depleted from not eating or drinking as much, said Dr Stephen ORahilly, co-director of the Institute of Metabolic Science at the University of Cambridge
If your situation fits these criteria, continue with careful monitoring
Discussion This is the case of a 44 year old man with extreme, refractory obesity who successfully underwent a 21 day water fast in combination with GLP-1 treatment prior to bariatric surgery
When GLP-1 reaches the pancreas, it binds to GLP-1 receptors (GLP-1R) expressed on the pancreatic cells, stimulating insulin release
However, these parameters derive entirely from animal studies, and optimal human administration strategies remain undefined
