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Mouse lymphoma model and tumor xenografts The previously described mouse model of Burkitt lymphoma C57BL/6N-Tg(IGL-MYC)3Hm (-MYC mice) [35] was obtained from the NCI mouse repository (Strain code 01XA7), backcrossed to C57BL/6J for more than 10 generations, and maintained in heterozygosity in a C57BL/6 J background
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In mouse models with specific knockouts of the MLL4 and ALOX12B genes, skin pathological changes similar to ichthyosis, including epidermal hyperplasia and desquamation, were observed (141)
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