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Abstract Background Melatonin supplementation has gained considerable attention for its potential health impacts

Clinical trials involving approximately 900 participants found that the peptides adverse event profile was indistinguishable from placebo for most parameters, with no serious adverse events attributed to treatment

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Sekiguchi N, Kameda H, Amano K, Takeuchi T: Efficacy and safety of bucillamine, a D-penicillamine analogue, in patients with active rheumatoid arthritis

The biological plausibility can assess whether there is a mechanism to support the potential relationship between ADRs and the studied drug