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USA 110 , 88828887 (2013)
Given that inhibition of IGF-IR may paradoxically lead to upregulation of IGF1/2 expression, and IGF1/2 have IGF-IR/InsR-independent functions, it warrants to investigate whether co-targeting IGF and IGF-IR/InsR-A may achieve objective responses
The peak fractions (excluding those partially overlapping with the void volume peak) of the SEC-purified complex were pooled and concentrated to 6 mg ml 1
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The rectal route of administration can be particularly useful for patients who have difficulties with oral ingestion or for those who require a rapid onset of action
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