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The challenge test measures the ability of the adrenal gland to secrete cortisol in response to exogenously administered ACTH

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We have already observed that BL patients have weaker correlations within the TRP pathway, e.g., 5-HIAA with TRP (tau = 0.09 BL, tau = 0.69 HC), which may occur when dietary associations are overcome by other rate-limiting pathway controls based on physiological needs for serotonin neurotransmitter (Yao et al., 2010a)