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In a Mayo Clinic study presented at an annual meeting of the Endocrine Society in July 2025, researchers found that, over 18 months, 40 postmenopausal women who combined the GLP-1 drug tirzepatide (used in Mounjaro and Zepbound) with hormone therapy lost an average of 17 percent of their body weight

According to FDA labeling, a gradual dose-escalation protocol allows patients to adjust over time, starting at 0.25 mg and increasing to a maintenance dose of 2.4 mg

If youre an Ozempic user and you notice any significant changes in your facial skin condition, do not hesitate to consult with your healthcare provider

"Ozempic face can also result from a disproportionate loss of muscle tissue due to unintentional and poor eating habits among patients taking GLP-1 medication like Ozempic