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BMI, 37.8 [6.8] kg/m2

Finally, it is also notable, in light of the reduction in mitochondrial subunit expression seen in the downregulated dataset, that multiple respirasome proteins were also found to be upregulated, including electron transfer flavoprotein-ubiquinone oxidoreductase, which is responsible for linking fatty acid and amino acid degradation with oxidative phosphorylation and was increased 1.3-fold (p=0.023)

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Moreover, GLP-1RA negatively influences the expression of peroxisome proliferator-activated receptors (PPARs), leading to a downregulation of proteins associated with lipid metabolism (37, 41, 42)