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One year after diet-induced weight loss of about 13.5 kg, leptin remained 35% below baseline

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At 265 lb, exposure ran 21% to 33% lower the spread reflects genuine disagreement between the two class models and the FDAs own reading of one of them, not measurement noise. On that class-based model, 1 mg in a 155 lb person can approximate the exposure produced by 1.5 mg in the 240 lb trial cohort