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6a, b) Delaying G6PDi-1 treatment for 1 h post-stimulation allowed for substantial cytokine production, indicating that G6PD and the PPP likely play an important role in the early signaling events following stimulation
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Therefore, for optimal results, injection is generally recommended
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When systemic glutathione levels are low, the resulting unchecked oxidative stress acts as a constant irritant to mast cells, keeping them in a hyper-reactive state
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