A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient
On chromosome 1, we observed a significant number of associated variants near the TMCO1 gene, which has been implicated in various disorders, including POAG, craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 25
2021;600:120520 Najmi AW S, Huang Y, Alqahtani Y, Seefeldt T, Guan X
Dietary strategies that enhance insulin sensitivity, such as regular moderate carbohydrate portions, unsaturated fats, fiber, and micronutrient-dense foods, aid in normalizing these hormonal signals and creating a receptive endometrium
However, there may be a link between vitamin B12 and weight loss in people with a B12 deficiency
