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Why: Less effective than IV or IM as less effective due to slower absorption and less direct absorption

However, safety assessments of oral semaglutide in the SOUL trial ( 5 Conclusion Semaglutide significantly reduces cardiovascular risk in patients with T2DM, primarily by improving MACE, nonfatal myocardial infarction, and revascularization outcomes, while modestly lowering HF hospitalization risk

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Women whove had hysterectomies sometimes need slightly different dosing than women taking combined therapy, as progesterone can affect estrogen metabolism