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Clinical trials conducted by Eli Lilly, the manufacturer of tirzepatide, found that fatigue affects approximately 5% of people taking the 5mg dose, 6% on the 10mg dose, and 7% on the 15mg dose

These conformational changes impact the binding of the G-protein through a series of hydrophobic interactions and some specific non-polar interactions

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doi: 10.1034/j.1399-3054.2002.1140201.x 8 Clemente-MorenoM