GLP-1 receptor agonists may cause fatigue through reduced caloric intake, gastrointestinal symptoms affecting nutrition and hydration, changes in blood glucose regulation, and the body's adaptation period to the medication
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For example, a randomized, double-blind, placebo-controlled trial in patients with overweight or obesity -associated KOA assessed the effects of liraglutide (3 mg/day) over 52 weeks as an add-on to dietary guidance [47, 48]